Invited Speaker
Prof. Xusheng Shao
Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, ChinaSpeech Title: Photopharmacological ligands for Pesticides
Abstract: Photopharmacological ligands provide a powerful way for optical control of the activity of a molecule, which will facilitate better understanding of toxicological mechanism. By blending of photoswitch with pesticides, we prepared series of photochromic ligands acting on various receptors or enzymes, such as nAChR, GABAR, sodium channel, Ryanodine receptor. Some PCLs showed different activity before and after light irradiation. These PCLs were then used to optically control over the enzyme, neuron and insect behavioral responses.
Biography: Xusheng Shao received his Ph.D. degree in Applied Chemistry from East China University of Science and Technology in 2009. He spent one year at University of California, Berkeley from 2012 to 2013. Currently, he is a professor of ECUST. His research interest focuses on green pesticides and photochemistry-based pesticides. He published more than 80 papers and one of the inventors of insecticides Paichongding and Cycloxaprid. He was supported by National Key R&D Program of China, Natural Science Foundation of China and Ten-thousand Talents Program-Youth talent. He is the youth editorial member of Chinese Chemical Letters and the member of American Chemical Society.